Clinical Perspectives: Multiple Myeloma and Serum Protein Electrophoresis

As a physician, a patient comes to you presenting with bone pain, weight loss, nausea and vomiting. Ordered tests come back abnormal: the complete blood count (CBC) shows low cell counts with abnormal cells, calcium, urea and creatinine levels are elevated, and the X-ray demonstrates bone lesions. All these signs point towards multiple myeloma, a type of cancer in which plasma cells form multiple masses in the bone marrow. Therefore, a serum protein electrophoresis is ordered to confirm your suspicion. Continue reading